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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
ACHE
All Species:
20.3
Human Site:
T143
Identified Species:
34.36
UniProt:
P22303
Number Species:
13
Phosphosite Substitution
Charge Score:
0
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P22303
NP_000656.1
614
67796
T143
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
Chimpanzee
Pan troglodytes
XP_516857
643
72946
A176
P
A
P
K
P
K
N
A
T
V
L
I
W
I
Y
Rhesus Macaque
Macaca mulatta
NP_001121560
614
67754
T143
Y
P
R
P
T
S
P
T
P
V
L
V
W
I
Y
Dog
Lupus familis
XP_546946
611
67308
T140
Y
P
R
P
A
S
P
T
P
V
L
V
W
I
Y
Cat
Felis silvestris
Mouse
Mus musculus
P21836
614
68150
T143
Y
P
R
P
A
S
P
T
P
V
L
I
W
I
Y
Rat
Rattus norvegicus
P37136
614
68178
T143
Y
P
R
P
T
S
P
T
P
V
L
I
W
I
Y
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001505841
602
68511
A135
P
S
P
K
P
K
N
A
T
V
M
V
W
I
Y
Chicken
Gallus gallus
P36196
767
83002
P136
Q
K
G
D
P
T
E
P
P
V
L
V
W
I
Y
Frog
Xenopus laevis
NP_001121332
600
68177
T133
H
P
R
P
S
N
A
T
V
M
V
W
I
Y
G
Zebra Danio
Brachydanio rerio
Q9DDE3
634
71980
L134
P
T
P
R
P
Q
N
L
T
V
M
V
W
I
Y
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P07140
649
71767
G147
A
K
A
R
L
R
H
G
R
G
A
N
G
G
E
Honey Bee
Apis mellifera
XP_393751
657
73886
A174
R
P
R
P
T
N
A
A
V
M
V
W
I
F
G
Nematode Worm
Caenorhab. elegans
P38433
620
71415
K125
G
K
V
D
P
N
K
K
L
A
V
M
V
W
V
Sea Urchin
Strong. purpuratus
XP_782113
508
56946
E98
G
C
F
H
F
P
D
E
T
F
P
G
F
R
G
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
48.9
99.5
92.8
N.A.
88.4
88.5
N.A.
50.6
47.9
59.6
60
N.A.
34.3
39.8
41.2
37.7
Protein Similarity:
100
66.8
99.6
96
N.A.
93
93.6
N.A.
68.2
58
73.4
73.6
N.A.
51.4
56.9
56.9
51.6
P-Site Identity:
100
33.3
100
93.3
N.A.
86.6
93.3
N.A.
33.3
46.6
26.6
33.3
N.A.
0
26.6
0
0
P-Site Similarity:
100
40
100
93.3
N.A.
93.3
100
N.A.
40
53.3
60
40
N.A.
0
46.6
20
6.6
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
8
8
8
0
15
0
15
22
0
8
8
0
0
0
0
% A
% Cys:
0
8
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
15
0
0
8
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
0
0
0
0
8
8
0
0
0
0
0
0
8
% E
% Phe:
0
0
8
0
8
0
0
0
0
8
0
0
8
8
0
% F
% Gly:
15
0
8
0
0
0
0
8
0
8
0
8
8
8
22
% G
% His:
8
0
0
8
0
0
8
0
0
0
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
0
22
15
65
0
% I
% Lys:
0
22
0
15
0
15
8
8
0
0
0
0
0
0
0
% K
% Leu:
0
0
0
0
8
0
0
8
8
0
50
0
0
0
0
% L
% Met:
0
0
0
0
0
0
0
0
0
15
15
8
0
0
0
% M
% Asn:
0
0
0
0
0
22
22
0
0
0
0
8
0
0
0
% N
% Pro:
22
50
22
50
36
8
36
8
43
0
8
0
0
0
0
% P
% Gln:
8
0
0
0
0
8
0
0
0
0
0
0
0
0
0
% Q
% Arg:
8
0
50
15
0
8
0
0
8
0
0
0
0
8
0
% R
% Ser:
0
8
0
0
8
36
0
0
0
0
0
0
0
0
0
% S
% Thr:
0
8
0
0
29
8
0
43
29
0
0
0
0
0
0
% T
% Val:
0
0
8
0
0
0
0
0
15
65
22
43
8
0
8
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
15
65
8
0
% W
% Tyr:
36
0
0
0
0
0
0
0
0
0
0
0
0
8
65
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _